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Jonathan D. Wren

TitleAssociate Member
InstitutionOklahoma Medical Research Foundation
DepartmentArthritis and Clinical Immunology
Address825 N.E. 13th Street
Oklahoma City OK 73104
Phone405-372-6989
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bodas M, Moore AR, Subramaniyan B, Georgescu C, Wren JD, Freeman WM, Brown BR, Metcalf JP, Walters MS. Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2021 Apr; 64(4):426-440. PMID: 33444514.
      Citations:    Fields:    
    2. Sun G, Chen J, Ding Y, Wren JD, Xu F, Lu L, Wang Y, Wang DW, Zhang XA. A Bioinformatics Perspective on the Links Between Tetraspanin-Enriched Microdomains and Cardiovascular Pathophysiology. Front Cardiovasc Med. 2021; 8:630471. PMID: 33860000.
      Citations:    
    3. Kurup K, Matyi S, Giles CB, Wren JD, Jones K, Ericsson A, Raftery D, Wang L, Promislow D, Richardson A, Unnikrishnan A. Calorie restriction prevents age-related changes in the intestinal microbiota. Aging (Albany NY). 2021 03 10; 13(5):6298-6329. PMID: 33744869.
      Citations:    
    4. Corbin JM, Georgescu C, Wren JD, Xu C, Asch AS, Ruiz-Echevarría MJ. Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Mol Ther Nucleic Acids. 2021 Jun 04; 24:337-351. PMID: 33850637.
      Citations:    
    5. Dwivedi SKD, Rao G, Dey A, Mukherjee P, Wren JD, Bhattacharya R. Small Non-Coding-RNA in Gynecological Malignancies. Cancers (Basel). 2021 Mar 03; 13(5). PMID: 33802524.
      Citations:    
    6. Qaisar R, Pharaoh G, Bhaskaran S, Xu H, Ranjit R, Bian J, Ahn B, Georgescu C, Wren JD, Van Remmen H. Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. Int J Mol Sci. 2020 Dec 22; 22(1). PMID: 33375170.
      Citations:    Fields:    
    7. Bajana S, Thomas K, Georgescu C, Zhao Y, Wren JD, Kovats S, Sun XH. Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Front Immunol. 2020; 11:577718. PMID: 33391258.
      Citations:    Fields:    
    8. Ortiz-Fernández L, Saruhan-Direskeneli G, Alibaz-Oner F, Kaymaz-Tahra S, Coit P, Kong X, Kiprianos AP, Maughan RT, Aydin SZ, Aksu K, Keser G, Kamali S, Inanc M, Springer J, Akar S, Onen F, Akkoc N, Khalidi NA, Koening C, Karadag O, Kiraz S, Forbess L, Langford CA, McAlear CA, Ozbalkan Z, Yavuz S, Çetin GY, Alpay-Kanitez N, Chung S, Ates A, Karaaslan Y, McKinnon-Maksimowicz K, Monach PA, Ozer HTE, Seyahi E, Fresko I, Cefle A, Seo P, Warrington KJ, Ozturk MA, Ytterberg SR, Cobankara V, Onat AM, Duzgun N, Bicakcigil M, Yentür SP, Lally L, Manfredi AA, Baldissera E, Erken E, Yazici A, Kisacik B, Kasifoglu T, Dalkilic E, Cuthbertson D, Pagnoux C, Sreih A, Reales G, Wallace C, Wren JD, Cunninghame-Graham DS, Vyse TJ, Sun Y, Chen H, Grayson PC, Tombetti E, Jiang L, Mason JC, Merkel PA, Direskeneli H, Sawalha AH. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study. Am J Hum Genet. 2021 01 07; 108(1):84-99. PMID: 33308445.
      Citations:    Fields:    Translation:Humans
    9. Gurley JM, Gmyrek GB, McClellan ME, Hargis EA, Hauck SM, Dozmorov MG, Wren JD, Carr DJJ, Elliott MH. Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina. Invest Ophthalmol Vis Sci. 2020 10 01; 61(12):19. PMID: 33079993.
      Citations:    Fields:    
    10. Rao G, Dwivedi SKD, Zhang Y, Dey A, Shameer K, Karthik R, Srikantan S, Hossen MN, Wren JD, Madesh M, Dudley JT, Bhattacharya R, Mukherjee P. MicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer. EMBO Rep. 2020 10 05; 21(10):e48483. PMID: 32851774.
      Citations: 1     Fields:    
    11. Peng V, Georgescu C, Bakowska A, Pankow A, Qian L, Wren JD, Sun XH. E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells. J Biol Chem. 2020 10 30; 295(44):14866-14877. PMID: 32817168.
      Citations: 1     Fields:    
    12. Pharaoh G, Brown JL, Sataranatarajan K, Kneis P, Bian J, Ranjit R, Hadad N, Georgescu C, Rabinovitch P, Ran Q, Wren JD, Freeman W, Kinter M, Richardson A, Van Remmen H. Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia. Sci Rep. 2020 08 18; 10(1):13968. PMID: 32811851.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Wolff CA, Lawrence MM, Porter H, Zhang Q, Reid JJ, Laurin JL, Musci RV, Linden MA, Peelor FF, Wren JD, Creery JS, Cutler KJ, Carson RH, Price JC, Hamilton KL, Miller BF. Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin. Geroscience. 2020 Aug 05. PMID: 32761290.
      Citations:    Fields:    
    14. Joachims ML, Leehan KM, Dozmorov MG, Georgescu C, Pan Z, Lawrence C, Marlin MC, Macwana S, Rasmussen A, Radfar L, Lewis DM, Stone DU, Grundahl K, Scofield RH, Lessard CJ, Wren JD, Thompson LF, Guthridge JM, Sivils KL, Moore JS, Farris AD. Sjögren's Syndrome Minor Salivary Gland CD4+ Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile. J Clin Med. 2020 Jul 08; 9(7). PMID: 32650575.
      Citations:    
    15. Wren JD, Bai Y, Qin ZS, Yan D, Homayouni R. Proceedings of the 2019 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2020 07 06; 21(Suppl 4):254. PMID: 32631224.
      Citations:    Fields:    
    16. Sapkota H, Wren JD, Gorbsky GJ. CSAG1 maintains the integrity of the mitotic centrosome in cells with defective p53. J Cell Sci. 2020 05 27; 133(10). PMID: 32295846.
      Citations: 1     Fields:    
    17. Sataranatarajan K, Pharaoh G, Brown JL, Ranjit R, Piekarz KM, Street K, Wren JD, Georgescu C, Kinter C, Kinter M, Freeman WM, Richardson A, Van Remmen H. Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia. Geroscience. 2020 08; 42(4):1101-1118. PMID: 32394347.
      Citations: 2     Fields:    
    18. Medley SC, Rathnakar BH, Georgescu C, Wren JD, Olson LE. Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair. Wound Repair Regen. 2020 07; 28(4):448-459. PMID: 32175700.
      Citations:    Fields:    
    19. Kiss T, Tarantini S, Csipo T, Balasubramanian P, Nyúl-Tóth Á, Yabluchanskiy A, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z. Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood. Geroscience. 2020 04; 42(2):727-748. PMID: 32172434.
      Citations: 4     Fields:    Translation:HumansAnimals
    20. Kiss T, Nyúl-Tóth Á, Balasubramanian P, Tarantini S, Ahire C, Yabluchanskiy A, Csipo T, Farkas E, Wren JD, Garman L, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020 04; 42(2):527-546. PMID: 32056076.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Dwivedi SKD, Shameer K, Dey A, Mustafi SB, Xiong X, Bhattacharya U, Neizer-Ashun F, Rao G, Wang Y, Ivan C, Yang D, Dudley JT, Xu C, Wren JD, Mukherjee P, Bhattacharya R. KRCC1: A potential therapeutic target in ovarian cancer. FASEB J. 2020 02; 34(2):2287-2300. PMID: 31908025.
      Citations:    Fields:    Translation:HumansCells
    22. Zalles M, Smith N, Ziegler J, Saunders D, Remerowski S, Thomas L, Gulej R, Mamedova N, Lerner M, Fung KM, Chung J, Hwang K, Jin J, Wiley G, Brown C, Battiste J, Wren JD, Towner RA. Optimized monoclonal antibody treatment against ELTD1 for GBM in a G55 xenograft mouse model. J Cell Mol Med. 2020 01; 24(2):1738-1749. PMID: 31863639.
      Citations: 2     Fields:    
    23. Barnett AG, Wren JD. Examination of CIs in health and medical journals from 1976 to 2019: an observational study. BMJ Open. 2019 11 21; 9(11):e032506. PMID: 31753893.
      Citations:    Fields:    
    24. Harris VM, Koelsch KA, Kurien BT, Harley ITW, Wren JD, Harley JB, Scofield RH. Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis. Front Immunol. 2019; 10:2160. PMID: 31695690.
      Citations: 2     Fields:    Translation:HumansCells
    25. Wren JD, Valencia A, Kelso J. Reviewer-coerced citation: case report, update on journal policy and suggestions for future prevention. Bioinformatics. 2019 09 15; 35(18):3217-3218. PMID: 30698640.
      Citations: 3     Fields:    
    26. Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Csipo T, Nyúl-Tóth Á, Lipecz A, Szabo C, Farkas E, Wren JD, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. Geroscience. 2019 08; 41(4):419-439. PMID: 31463647.
      Citations: 14     Fields:    Translation:Animals
    27. Georgescu C, Corbin JM, Thibivilliers S, Webb ZD, Zhao YD, Koster J, Fung KM, Asch AS, Wren JD, Ruiz-Echevarría MJ. A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer. BMC Cancer. 2019 May 06; 19(1):423. PMID: 31060542.
      Citations: 2     Fields:    Translation:HumansCells
    28. Wood AC, Wren JD, Allison DB. The Need for Greater Rigor in Childhood Nutrition and Obesity Research. JAMA Pediatr. 2019 04 01; 173(4):311-312. PMID: 30801651.
      Citations: 3     Fields:    Translation:Humans
    29. Qian L, Bajana S, Georgescu C, Peng V, Wang HC, Adrianto I, Colonna M, Alberola-Ila J, Wren JD, Sun XH. Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019 04 01; 216(4):884-899. PMID: 30898894.
      Citations: 6     Fields:    Translation:AnimalsCells
    30. Perz AI, Giles CB, Brown CA, Porter H, Roopnarinesingh X, Wren JD. MNEMONIC: MetageNomic Experiment Mining to create an OTU Network of Inhabitant Correlations. BMC Bioinformatics. 2019 Mar 14; 20(Suppl 2):96. PMID: 30871469.
      Citations:    Fields:    Translation:Humans
    31. Wren JD, Doerkson RJ, Toby IT, Nanduri B, Homayouni R, Manda P, Thakkar S. Proceedings of the 2018 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference. BMC Bioinformatics. 2019 Mar 14; 20(Suppl 2):95. PMID: 30871470.
      Citations:    Fields:    Translation:Humans
    32. Ziegler J, Zalles M, Smith N, Saunders D, Lerner M, Fung KM, Patel M, Wren JD, Lupu F, Battiste J, Towner RA. Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment. Am J Nucl Med Mol Imaging. 2019; 9(1):93-109. PMID: 30911439.
      Citations:    
    33. Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 02 15; 74(3):290-298. PMID: 29893815.
      Citations: 14     Fields:    Translation:Animals
    34. Shah HB, Smith K, Wren JD, Webb CF, Ballard JD, Bourn RL, James JA, Lang ML. Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires. Front Immunol. 2018; 9:3064. PMID: 30697210.
      Citations: 4     Fields:    Translation:HumansCells
    35. Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR. CAGm: a repository of germline microsatellite variations in the 1000 genomes project. Nucleic Acids Res. 2019 01 08; 47(D1):D39-D45. PMID: 30329086.
      Citations: 1     Fields:    Translation:HumansCells
    36. Towner RA, Smith N, Saunders D, Brown CA, Cai X, Ziegler J, Mallory S, Dozmorov MG, Coutinho De Souza P, Wiley G, Kim K, Kang S, Kong DS, Kim YT, Fung KM, Wren JD, Battiste J. OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth. Transl Oncol. 2019 Feb; 12(2):320-335. PMID: 30468988.
      Citations:    
    37. Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A. The role of DNA methylation in epigenetics of aging. Pharmacol Ther. 2019 03; 195:172-185. PMID: 30419258.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    38. Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connell SA, Chen T, Zhang XA. Correction to: Tetraspanin-enriched microdomains regulate digitation junctions. Cell Mol Life Sci. 2018 11; 75(21):4077. PMID: 30196315.
      Citations:    Fields:    
    39. Ratliff ML, Garton J, Garman L, Barron MD, Georgescu C, White KA, Chakravarty E, Wren JD, Montgomery CG, James JA, Webb CF. ARID3a gene profiles are strongly associated with human interferon alpha production. J Autoimmun. 2019 01; 96:158-167. PMID: 30297159.
      Citations: 4     Fields:    Translation:HumansCells
    40. Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A. Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nat Rev Cardiol. 2018 09; 15(9):555-565. PMID: 29795441.
      Citations: 45     Fields:    Translation:HumansAnimals
    41. Wren JD. Algorithmically outsourcing the detection of statistical errors and other problems. EMBO J. 2018 06 15; 37(12). PMID: 29794111.
      Citations:    Fields:    
    42. Georgescu C, Wren JD. Algorithmic identification of discrepancies between published ratios and their reported confidence intervals and P-values. Bioinformatics. 2018 05 15; 34(10):1758-1766. PMID: 29309530.
      Citations: 4     Fields:    Translation:Humans
    43. Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H. Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Aging Cell. 2018 08; 17(4):e12769. PMID: 29696791.
      Citations: 3     Fields:    Translation:AnimalsCells
    44. Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connel SA, Chen T, Zhang XA. Tetraspanin-enriched microdomains regulate digitation junctions. Cell Mol Life Sci. 2018 09; 75(18):3423-3439. PMID: 29589089.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    45. Min KW, Zealy RW, Davila S, Fomin M, Cummings JC, Makowsky D, Mcdowell CH, Thigpen H, Hafner M, Kwon SH, Georgescu C, Wren JD, Yoon JH. Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. Aging Cell. 2018 06; 17(3):e12753. PMID: 29573145.
      Citations: 18     Fields:    Translation:HumansCells
    46. Buckley DA, Jennings EM, Burke NN, Roche M, McInerney V, Wren JD, Finn DP, McHugh PC. Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain. Mol Neurobiol. 2018 03; 55(3):2431. PMID: 28669124.
      Citations:    Fields:    
    47. Lever J, Gakkhar S, Gottlieb M, Rashnavadi T, Lin S, Siu C, Smith M, Jones MR, Krzywinski M, Jones SJM, Wren J. A collaborative filtering-based approach to biomedical knowledge discovery. Bioinformatics. 2018 02 15; 34(4):652-659. PMID: 29028901.
      Citations: 4     Fields:    
    48. Kulmanov M, Khan MA, Hoehndorf R, Wren J. DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier. Bioinformatics. 2018 02 15; 34(4):660-668. PMID: 29028931.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    49. Hoyt CT, Konotopez A, Ebeling C, Wren J. PyBEL: a computational framework for Biological Expression Language. Bioinformatics. 2018 02 15; 34(4):703-704. PMID: 29048466.
      Citations: 7     Fields:    Translation:HumansCells
    50. Uppal K, Ma C, Go YM, Jones DP, Wren J. xMWAS: a data-driven integration and differential network analysis tool. Bioinformatics. 2018 02 15; 34(4):701-702. PMID: 29069296.
      Citations: 33     Fields:    Translation:AnimalsCells
    51. Lagunin A, Rudik A, Druzhilovsky D, Filimonov D, Poroikov V, Wren J. ROSC-Pred: web-service for rodent organ-specific carcinogenicity prediction. Bioinformatics. 2018 02 15; 34(4):710-712. PMID: 29069300.
      Citations:    Fields:    Translation:Animals
    52. Huang X, Zhang S, Li K, Thimmapuram J, Xie S, Wren J. ViewBS: a powerful toolkit for visualization of high-throughput bisulfite sequencing data. Bioinformatics. 2018 02 15; 34(4):708-709. PMID: 29087450.
      Citations: 5     Fields:    Translation:AnimalsCells
    53. Giles CB, Brown CA, Ripperger M, Dennis Z, Roopnarinesingh X, Porter H, Perz A, Wren JD. ALE: automated label extraction from GEO metadata. BMC Bioinformatics. 2017 12 28; 18(Suppl 14):509. PMID: 29297276.
      Citations: 2     Fields:    Translation:HumansAnimals
    54. Wren JD, Dozmorov MG, Toby I, Nanduri B, Homayouni R, Manda P, Thakkar S. Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2017 12 28; 18(Suppl 14):498. PMID: 29297277.
      Citations:    Fields:    
    55. Piccini A, Castroflorio E, Valente P, Guarnieri FC, Aprile D, Michetti C, Bramini M, Giansante G, Pinto B, Savardi A, Cesca F, Bachi A, Cattaneo A, Wren JD, Fassio A, Valtorta F, Benfenati F, Giovedì S. APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Cell Rep. 2017 Dec 19; 21(12):3596-3611. PMID: 29262337.
      Citations: 2     Fields:    Translation:AnimalsCells
    56. Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP. Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol. 2018 02; 55(2):1795-1813. PMID: 29168048.
      Citations: 4     Fields:    Translation:AnimalsCells
    57. Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ. Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model. Stem Cell Res. 2018 01; 26:1-7. PMID: 29179130.
      Citations: 2     Fields:    Translation:HumansCells
    58. Gensterblum E, Renauer P, Coit P, Strickland FM, Kilian NC, Miller S, Ognenovski M, Wren JD, Tsou PS, Lewis EE, Maksimowicz-McKinnon K, McCune WJ, Richardson BC, Sawalha AH. CD4+CD28+KIR+CD11ahi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients. J Autoimmun. 2018 01; 86:19-28. PMID: 29066026.
      Citations: 9     Fields:    Translation:HumansCells
    59. Masser DR, Hadad N, Porter HL, Mangold CA, Unnikrishnan A, Ford MM, Giles CB, Georgescu C, Dozmorov MG, Wren JD, Richardson A, Stanford DR, Freeman WM. Sexually divergent DNA methylation patterns with hippocampal aging. Aging Cell. 2017 12; 16(6):1342-1352. PMID: 28948711.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    60. Knight JS, Meng H, Coit P, Yalavarthi S, Sule G, Gandhi AA, Grenn RC, Mazza LF, Ali RA, Renauer P, Wren JD, Bockenstedt PL, Wang H, Eitzman DT, Sawalha AH. Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target. JCI Insight. 2017 09 21; 2(18). PMID: 28931754.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    61. Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ. GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol. 2017 10 02; 216(10):3117-3132. PMID: 28821562.
      Citations: 9     Fields:    Translation:HumansCells
    62. Talmon GA, Wren JD, Nguyen CL, Pour PM. Pancreatic Polypeptide Cell Proliferation in the Pancreas and Duodenum Coexisting in a Patient With Pancreatic Adenocarcinoma Treated With a GLP-1 Analog. Pancreas. 2017 07; 46(6):820-824. PMID: 28609372.
      Citations: 3     Fields:    Translation:HumansCells
    63. Siefert JC, Georgescu C, Wren JD, Koren A, Sansam CL. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res. 2017 08; 27(8):1406-1416. PMID: 28512193.
      Citations: 15     Fields:    Translation:AnimalsCells
    64. Unnikrishnan A, Jackson J, Matyi SA, Hadad N, Wronowski B, Georgescu C, Garrett KP, Wren JD, Freeman WM, Richardson A. Role of DNA methylation in the dietary restriction mediated cellular memory. Geroscience. 2017 06; 39(3):331-345. PMID: 28477138.
      Citations: 7     Fields:    Translation:AnimalsCells
    65. Wren JD, Georgescu C, Giles CB, Hennessey J. Use it or lose it: citations predict the continued online availability of published bioinformatics resources. Nucleic Acids Res. 2017 04 20; 45(7):3627-3633. PMID: 28334982.
      Citations: 5     Fields:    
    66. Arriens C, Wren JD, Munroe ME, Mohan C. Systemic lupus erythematosus biomarkers: the challenging quest. Rheumatology (Oxford). 2017 04 01; 56(suppl_1):i32-i45. PMID: 28013203.
      Citations: 22     Fields:    Translation:Humans
    67. Buckley DA, Jennings EM, Burke NN, Roche M, McInerney V, Wren JD, Finn DP, McHugh PC. The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain. Mol Neurobiol. 2018 03; 55(3):2420-2430. PMID: 28361271.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    68. Tarantini S, Valcarcel-Ares NM, Yabluchanskiy A, Springo Z, Fulop GA, Ashpole N, Gautam T, Giles CB, Wren JD, Sonntag WE, Csiszar A, Ungvari Z. Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. 2017 06; 16(3):469-479. PMID: 28295976.
      Citations: 24     Fields:    Translation:AnimalsCells
    69. Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 02 01; 19(2):175-185. PMID: 27416955.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    70. Larabee CM, Desai S, Agasing A, Georgescu C, Wren JD, Axtell RC, Plafker SM. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. Mol Vis. 2016; 22:1503-1513. PMID: 28050123.
      Citations: 15     Fields:    Translation:AnimalsCells
    71. Tsou PS, Wren JD, Amin MA, Schiopu E, Fox DA, Khanna D, Sawalha AH. Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. Arthritis Rheumatol. 2016 12; 68(12):2975-2985. PMID: 27482699.
      Citations: 19     Fields:    Translation:HumansCells
    72. Salmon AB, Kim G, Liu C, Wren JD, Georgescu C, Richardson A, Levine RL. Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice. Redox Biol. 2016 12; 10:251-256. PMID: 27821326.
      Citations: 6     Fields:    Translation:AnimalsCells
    73. Wren JD, Toby I, Hong H, Nanduri B, Kaundal R, Dozmorov MG, Thakkar S. Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2016 10 06; 17(Suppl 13):356. PMID: 27766933.
      Citations:    Fields:    
    74. Stock AJ, Kasus-Jacobi A, Wren JD, Sjoelund VH, Prestwich GD, Pereira HA. The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. PLoS One. 2016; 11(9):e0163330. PMID: 27676391.
      Citations: 5     Fields:    
    75. Wren JD. Clinical trial IDs need to be validated prior to publication because hundreds of invalid National Clinical Trial Identifications are regularly entering MEDLINE. Clin Trials. 2017 02; 14(1):109. PMID: 27625315.
      Citations: 1     Fields:    
    76. Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr). 2016 Aug; 38(4):273-289. PMID: 27613724.
      Citations: 31     Fields:    Translation:HumansAnimals
    77. Coit P, Dozmorov MG, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Wren JD, Sawalha AH. Epigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non-Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares. Arthritis Rheumatol. 2016 09; 68(9):2200-9. PMID: 27111767.
      Citations: 23     Fields:    Translation:HumansCells
    78. Tarantini S, Giles CB, Wren JD, Ashpole NM, Valcarcel-Ares MN, Wei JY, Sonntag WE, Ungvari Z, Csiszar A. IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr). 2016 Aug; 38(4):239-258. PMID: 27566308.
      Citations: 15     Fields:    Translation:AnimalsCells
    79. Kushwaha G, Dozmorov M, Wren JD, Qiu J, Shi H, Xu D. Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia. Hum Genomics. 2016 07 25; 10 Suppl 2:18. PMID: 27461342.
      Citations: 12     Fields:    Translation:HumansCells
    80. Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin. 2016; 9:30. PMID: 27413395.
      Citations: 22     Fields:    
    81. Kim TD, Oh S, Lightfoot SA, Shin S, Wren JD, Janknecht R. Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int J Clin Exp Med. 2016; 9(6):10123-10134. PMID: 28883898.
      Citations:    
    82. Wren JD. Bioinformatics programs are 31-fold over-represented among the highest impact scientific papers of the past two decades. Bioinformatics. 2016 09 01; 32(17):2686-91. PMID: 27153671.
      Citations: 10     Fields:    Translation:Humans
    83. Masser DR, Stanford DR, Hadad N, Giles CB, Wren JD, Sonntag WE, Richardson A, Freeman WM. Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordr). 2016 Jun; 38(3):49. PMID: 27091453.
      Citations: 7     Fields:    Translation:AnimalsCells
    84. Larabee CM, Hu Y, Desai S, Georgescu C, Wren JD, Axtell RC, Plafker SM. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice. Mol Vis. 2016; 22:332-41. PMID: 27122964.
      Citations: 3     Fields:    Translation:AnimalsCells
    85. Dozmorov MG, Cara LR, Giles CB, Wren JD. GenomeRunner web server: regulatory similarity and differences define the functional impact of SNP sets. Bioinformatics. 2016 08 01; 32(15):2256-63. PMID: 27153607.
      Citations: 11     Fields:    
    86. Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 2016 06; 15(3):428-35. PMID: 26711051.
      Citations: 180     Fields:    Translation:HumansAnimalsCells
    87. Sun C, Molineros JE, Looger LL, Zhou XJ, Kim K, Okada Y, Ma J, Qi YY, Kim-Howard X, Motghare P, Bhattarai K, Adler A, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Kochi Y, Suzuki A, Kubo M, Sumida T, Yamamoto K, Lee SS, Kim YJ, Han BG, Dozmorov M, Kaufman KM, Wren JD, Harley JB, Shen N, Chua KH, Zhang H, Bae SC, Nath SK. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. Nat Genet. 2016 Mar; 48(3):323-30. PMID: 26808113.
      Citations: 71     Fields:    Translation:Humans
    88. Mangold CA, Masser DR, Stanford DR, Bixler GV, Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag WE, Freeman WM. CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. J Gerontol A Biol Sci Med Sci. 2017 01; 72(1):16-29. PMID: 26786204.
      Citations: 16     Fields:    Translation:AnimalsCells
    89. Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016 Feb; 126(2):706-20. PMID: 26731476.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    90. Feng J, Huang C, Wren JD, Wang DW, Yan J, Zhang J, Sun Y, Han X, Zhang XA. Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity. Cancer Metastasis Rev. 2015 Dec; 34(4):619-33. PMID: 26335499.
      Citations: 12     Fields:    Translation:HumansCells
    91. Coit P, Ognenovski M, Gensterblum E, Maksimowicz-McKinnon K, Wren JD, Sawalha AH. Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity. Epigenetics Chromatin. 2015; 8:49. PMID: 26609326.
      Citations: 20     Fields:    
    92. Larabee CM, Georgescu C, Wren JD, Plafker SM. Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons. BMC Neurosci. 2015 Nov 13; 16:76. PMID: 26566974.
      Citations: 2     Fields:    Translation:AnimalsCells
    93. Tafur AJ, Dale G, Cherry M, Wren JD, Mansfield AS, Comp P, Rathbun S, Stoner JA. Prospective evaluation of protein C and factor VIII in prediction of cancer-associated thrombosis. Thromb Res. 2015 Dec; 136(6):1120-5. PMID: 26475410.
      Citations:    Fields:    Translation:Humans
    94. Corbin JM, Overcash RF, Wren JD, Coburn A, Tipton GJ, Ezzell JA, McNaughton KK, Fung KM, Kosanke SD, Ruiz-Echevarria MJ. Analysis of TMEFF2 allografts and transgenic mouse models reveals roles in prostate regeneration and cancer. Prostate. 2016 Jan; 76(1):97-113. PMID: 26417683.
      Citations: 3     Fields:    Translation:AnimalsCells
    95. Dozmorov MG, Adrianto I, Giles CB, Glass E, Glenn SB, Montgomery C, Sivils KL, Olson LE, Iwayama T, Freeman WM, Lessard CJ, Wren JD. Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data. BMC Bioinformatics. 2015; 16 Suppl 13:S10. PMID: 26423047.
      Citations: 8     Fields:    Translation:Humans
    96. Wren JD, Thakkar S, Homayouni R, Johann DJ, Dozmorov MG. Proceedings of the 2015 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2015; 16 Suppl 13:S1. PMID: 26424691.
      Citations:    Fields:    
    97. Fisch AS, Yerges-Armstrong LM, Backman JD, Wang H, Donnelly P, Ryan KA, Parihar A, Pavlovich MA, Mitchell BD, O'Connell JR, Herzog W, Harman CR, Wren JD, Lewis JP. Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction. PLoS One. 2015; 10(9):e0138795. PMID: 26406321.
      Citations: 10     Fields:    Translation:HumansCells
    98. Iwayama T, Steele C, Yao L, Dozmorov MG, Karamichos D, Wren JD, Olson LE. PDGFRa signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev. 2015 Jun 01; 29(11):1106-19. PMID: 26019175.
      Citations: 52     Fields:    Translation:AnimalsCells
    99. Renauer PA, Saruhan-Direskeneli G, Coit P, Adler A, Aksu K, Keser G, Alibaz-Oner F, Aydin SZ, Kamali S, Inanc M, Carette S, Cuthbertson D, Hoffman GS, Akar S, Onen F, Akkoc N, Khalidi NA, Koening C, Karadag O, Kiraz S, Langford CA, Maksimowicz-McKinnon K, McAlear CA, Ozbalkan Z, Ates A, Karaaslan Y, Duzgun N, Monach PA, Ozer HT, Erken E, Ozturk MA, Yazici A, Cefle A, Onat AM, Kisacik B, Pagnoux C, Kasifoglu T, Seyahi E, Fresko I, Seo P, Sreih AG, Warrington KJ, Ytterberg SR, Cobankara V, Cunninghame-Graham DS, Vyse TJ, Pamuk ON, Tunc SE, Dalkilic E, Bicakcigil M, Yentur SP, Wren JD, Merkel PA, Direskeneli H, Sawalha AH. Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study. Arthritis Rheumatol. 2015 May; 67(5):1361-8. PMID: 25604533.
      Citations: 21     Fields:    Translation:HumansCells
    100. Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14(4):644-58. PMID: 25754370.
      Citations: 372     Fields:    Translation:AnimalsCells
    101. Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015 Apr 15; 194(8):3820-8. PMID: 25780034.
      Citations: 7     Fields:    Translation:AnimalsCells
    102. Edgar CE, Terrell DR, Vesely SK, Wren JD, Dozmorov IM, Niewold TB, Brown M, Zhou F, Frank MB, Merrill JT, Kremer Hovinga JA, Lämmle B, James JA, George JN, Farris AD. Ribosomal and immune transcripts associate with relapse in acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura. PLoS One. 2015; 10(2):e0117614. PMID: 25671313.
      Citations:    Fields:    Translation:HumansCells
    103. Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, Wren JD, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell. 2015 Jun; 14(3):400-8. PMID: 25677910.
      Citations: 45     Fields:    Translation:AnimalsCells
    104. Coit P, Yalavarthi S, Ognenovski M, Zhao W, Hasni S, Wren JD, Kaplan MJ, Sawalha AH. Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils. J Autoimmun. 2015 Apr; 58:59-66. PMID: 25638528.
      Citations: 54     Fields:    Translation:HumansCells
    105. Hennessey J, Georgescu C, Wren JD. Trends in the production of scientific data analysis resources. BMC Bioinformatics. 2014; 15 Suppl 11:S7. PMID: 25350391.
      Citations: 3     Fields:    
    106. Wren JD, Dozmorov MG, Burian D, Perkins A, Zhang C, Hoyt P, Kaundal R. Proceedings of the 2014 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2014; 15 Suppl 11:I1. PMID: 25350879.
      Citations:    Fields:    
    107. Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal. 2014 Oct 14; 7(347):ra97. PMID: 25314967.
      Citations: 18     Fields:    Translation:AnimalsCells
    108. Wei Q, Zhang F, Richardson MM, Roy NH, Rodgers W, Liu Y, Zhao W, Fu C, Ding Y, Huang C, Chen Y, Sun Y, Ding L, Hu Y, Ma JX, Boulton ME, Pasula S, Wren JD, Tanaka S, Huang X, Thali M, Hämmerling GJ, Zhang XA. CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation. 2014 Oct 21; 130(17):1493-504. PMID: 25149363.
      Citations: 12     Fields:    Translation:AnimalsCells
    109. Masser DR, Bixler GV, Brucklacher RM, Yan H, Giles CB, Wren JD, Sonntag WE, Freeman WM. Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1311-24. PMID: 24994846.
      Citations: 20     Fields:    Translation:AnimalsCells
    110. Dozmorov MG, Yang Q, Wu W, Wren J, Suhail MM, Woolley CL, Young DG, Fung KM, Lin HK. Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study. Chin Med. 2014; 9:18. PMID: 25006348.
      Citations:    
    111. Csiszar A, Gautam T, Sosnowska D, Tarantini S, Banki E, Tucsek Z, Toth P, Losonczy G, Koller A, Reglodi D, Giles CB, Wren JD, Sonntag WE, Ungvari Z. Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. . 2014 Aug 01; 307(3):H292-306. PMID: 24906921.
      Citations:    
    112. Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1339-52. PMID: 24895269.
      Citations: 57     Fields:    Translation:AnimalsCells
    113. Towner RA, Wren JD. Prioritizing uncharacterized genes in the search for glioma biomarkers. CNS Oncol. 2014 Mar; 3(2):93-5. PMID: 25055012.
      Citations: 1     Fields:    Translation:Humans
    114. Dozmorov MG, Wren JD, Alarcón-Riquelme ME. Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes. Epigenetics. 2014 Feb; 9(2):276-85. PMID: 24213554.
      Citations: 19     Fields:    Translation:HumansCells
    115. Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD. Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro Oncol. 2013 Dec; 15(12):1625-34. PMID: 24158112.
      Citations: 17     Fields:    Translation:Humans
    116. Wren JD, Dozmorov MG, Burian D, Kaundal R, Perkins A, Perkins E, Kupfer DM, Springer GK. Proceedings of the 2013 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2013; 14 Suppl 14:S1. PMID: 24267415.
      Citations:    Fields:    Translation:HumansCells
    117. Giles CB, Girija-Devi R, Dozmorov MG, Wren JD. mirCoX: a database of miRNA-mRNA expression correlations derived from RNA-seq meta-analysis. BMC Bioinformatics. 2013; 14 Suppl 14:S17. PMID: 24267917.
      Citations: 9     Fields:    Translation:HumansCells
    118. Dozmorov MG, Giles CB, Koelsch KA, Wren JD. Systematic classification of non-coding RNAs by epigenomic similarity. BMC Bioinformatics. 2013; 14 Suppl 14:S2. PMID: 24267974.
      Citations: 18     Fields:    Translation:HumansCells
    119. Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet. 2013 Nov; 45(11):1284-92. PMID: 24097067.
      Citations: 133     Fields:    Translation:Humans
    120. Trevarton AJ, Mann MB, Knapp C, Araki H, Wren JD, Stones-Havas S, Black MA, Print CG. MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease-Associated Molecular Pathways. Front Oncol. 2013; 3:184. PMID: 23875173.
      Citations:    
    121. Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients. J Autoimmun. 2013 Jun; 43:78-84. PMID: 23623029.
      Citations: 108     Fields:    Translation:HumansCells
    122. Koelsch KA, Wang Y, Maier-Moore JS, Sawalha AH, Wren JD. GFP affects human T cell activation and cytokine production following in vitro stimulation. PLoS One. 2013; 8(4):e50068. PMID: 23577054.
      Citations: 7     Fields:    Translation:HumansCells
    123. Koelsch KA, Webb R, Jeffries M, Dozmorov MG, Frank MB, Guthridge JM, James JA, Wren JD, Sawalha AH. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun. 2013 Mar; 41:168-74. PMID: 23428850.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    124. Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, a potential new biomarker for gliomas. Neurosurgery. 2013 Jan; 72(1):77-90; discussion 91. PMID: 23096411.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    125. Wren JD, Dozmorov MG, Burian D, Kaundal R, Bridges S, Kupfer DM. Proceedings of the 2012 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference. Introduction. BMC Bioinformatics. 2012; 13 Suppl 15:S1. PMID: 23046182.
      Citations: 1     Fields:    
    126. Delgado-Vega AM, Dozmorov MG, Quirós MB, Wu YY, Martínez-García B, Kozyrev SV, Frostegård J, Truedsson L, de Ramón E, González-Escribano MF, Ortego-Centeno N, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Lauwerys BR, Endreffy E, Kovács L, Vasconcelos C, da Silva BM, Wren JD, Martin J, Castillejo-López C, Alarcón-Riquelme ME. Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein. Ann Rheum Dis. 2012 Jul; 71(7):1219-26. PMID: 22696686.
      Citations: 14     Fields:    Translation:HumansCells
    127. Peng H, Bateman A, Valencia A, Wren JD. Bioimage informatics: a new category in Bioinformatics. Bioinformatics. 2012 Apr 15; 28(8):1057. PMID: 22399678.
      Citations: 9     Fields:    
    128. Clemmensen SN, Bohr CT, Rørvig S, Glenthøj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N. Olfactomedin 4 defines a subset of human neutrophils. J Leukoc Biol. 2012 Mar; 91(3):495-500. PMID: 22187488.
      Citations: 49     Fields:    Translation:HumansCells
    129. Dozmorov MG, Cara LR, Giles CB, Wren JD. GenomeRunner: automating genome exploration. Bioinformatics. 2012 Feb 01; 28(3):419-20. PMID: 22155868.
      Citations: 19     Fields:    
    130. Wren JD, Kupfer DM, Perkins EJ, Bridges S, Winters-Hilt S, Dozmorov MG, Braga-Neto U. Proceedings of the 2011 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference. Introduction. BMC Bioinformatics. 2011 Oct 18; 12 Suppl 10:S1. PMID: 22165918.
      Citations:    Fields:    
    131. Dozmorov MG, Wren JD. High-throughput processing and normalization of one-color microarrays for transcriptional meta-analyses. BMC Bioinformatics. 2011 Oct 18; 12 Suppl 10:S2. PMID: 22166002.
      Citations: 11     Fields:    Translation:Humans
    132. Dozmorov MG, Giles CB, Wren JD. Predicting gene ontology from a global meta-analysis of 1-color microarray experiments. BMC Bioinformatics. 2011 Oct 18; 12 Suppl 10:S14. PMID: 22166114.
      Citations: 19     Fields:    Translation:Humans
    133. Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. Blood. 2011 Oct 20; 118(16):4463-71. PMID: 21868574.
      Citations: 31     Fields:    Translation:HumansCells
    134. Wren JD. Question answering systems in biology and medicine--the time is now. Bioinformatics. 2011 Jul 15; 27(14):2025-6. PMID: 21672971.
      Citations: 3     Fields:    Translation:Humans
    135. Jeffries MA, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics. 2011 May; 6(5):593-601. PMID: 21436623.
      Citations: 85     Fields:    Translation:HumansCells
    136. Dozmorov MG, Azzarello JT, Wren JD, Fung KM, Yang Q, Davis JS, Hurst RE, Culkin DJ, Penning TM, Lin HK. Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression. BMC Cancer. 2010 Dec 06; 10:672. PMID: 21134280.
      Citations: 18     Fields:    Translation:HumansCells
    137. Wren JD, Kupfer DM, Perkins EJ, Bridges S, Berleant D. Proceedings of the 2010 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference. BMC Bioinformatics. 2010 Oct 07; 11 Suppl 6:S1. PMID: 20946592.
      Citations:    Fields:    
    138. Hughes T, Webb R, Fei Y, Wren JD, Sawalha AH. DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks. Genes Immun. 2010 Oct; 11(7):554-60. PMID: 20463746.
      Citations: 20     Fields:    Translation:HumansCells
    139. Errami M, Sun Z, George AC, Long TC, Skinner MA, Wren JD, Garner HR. Identifying duplicate content using statistically improbable phrases. Bioinformatics. 2010 Jun 01; 26(11):1453-7. PMID: 20472545.
      Citations: 3     Fields:    
    140. Wren JD, Gusev Y, Isokpehi RD, Berleant D, Braga-Neto U, Wilkins D, Bridges S. Proceedings of the 2009 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference. Introduction. BMC Bioinformatics. 2009 Oct 08; 10 Suppl 11:S1. PMID: 19811674.
      Citations:    Fields:    
    141. Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ. Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis. Curr Biol. 2009 Sep 15; 19(17):1467-72. PMID: 19646878.
      Citations: 94     Fields:    Translation:HumansCells
    142. Wren JD. A global meta-analysis of microarray expression data to predict unknown gene functions and estimate the literature-data divide. Bioinformatics. 2009 Jul 01; 25(13):1694-701. PMID: 19447786.
      Citations: 59     Fields:    Translation:Humans
    143. Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum. 2009 Apr; 60(4):1076-84. PMID: 19333917.
      Citations: 44     Fields:    Translation:HumansCells
    144. Wren JD, Bateman A. Databases, data tombs and dust in the wind. Bioinformatics. 2008 Oct 01; 24(19):2127-8. PMID: 18819940.
      Citations: 13     Fields:    
    145. Wren JD, Wilkins D, Fuscoe JC, Bridges S, Winters-Hilt S, Gusev Y. Proceedings of the 2008 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2008 Aug 12; 9 Suppl 9:S1. PMID: 18793454.
      Citations: 1     Fields:    
    146. Giles CB, Wren JD. Large-scale directional relationship extraction and resolution. BMC Bioinformatics. 2008 Aug 12; 9 Suppl 9:S11. PMID: 18793456.
      Citations: 15     Fields:    Translation:Cells
    147. Wren JD. URL decay in MEDLINE--a 4-year follow-up study. Bioinformatics. 2008 Jun 01; 24(11):1381-5. PMID: 18413326.
      Citations: 17     Fields:    
    148. Wang H, Kesinger JW, Zhou Q, Wren JD, Martin G, Turner S, Tang Y, Frank MB, Centola M. Identification and characterization of zebrafish ocular formation genes. Genome. 2008 Mar; 51(3):222-35. PMID: 18356958.
      Citations: 7     Fields:    Translation:AnimalsCells
    149. Errami M, Hicks JM, Fisher W, Trusty D, Wren JD, Long TC, Garner HR. Déjà vu--a study of duplicate citations in Medline. Bioinformatics. 2008 Jan 15; 24(2):243-9. PMID: 18056062.
      Citations: 20     Fields:    
    150. Wren JD, Kozak KZ, Johnson KR, Deakyne SJ, Schilling LM, Dellavalle RP. The write position. A survey of perceived contributions to papers based on byline position and number of authors. . 2007 Nov; 8(11):988-91. PMID: 17972896.
      Citations:    
    151. Wilkins D, Gusev Y, Loganantharaj R, Bridges S, Winters-Hilt S, Wren JD. Proceedings of the Fourth Annual Conference of the MidSouth Computational Biology and Bioinformatics Society. BMC Bioinformatics. 2007 Nov 01; 8 Suppl 7:S1. PMID: 18047708.
      Citations: 1     Fields:    
    152. Wren JD, Wu Y, Guo SW. A system-wide analysis of differentially expressed genes in ectopic and eutopic endometrium. Hum Reprod. 2007 Aug; 22(8):2093-102. PMID: 17562676.
      Citations: 9     Fields:    Translation:Humans
    153. Burkart MF, Wren JD, Herschkowitz JI, Perou CM, Garner HR. Clustering microarray-derived gene lists through implicit literature relationships. Bioinformatics. 2007 Aug 01; 23(15):1995-2003. PMID: 17537751.
      Citations: 11     Fields:    
    154. Garner HR, Hicks J, Wren JD, Errami M. Medline: the knowledge buried therein, its potential, and cost. IEEE Eng Med Biol Mag. 2007 May-Jun; 26(3):73-4. PMID: 17549924.
      Citations: 2     Fields:    
    155. Errami M, Wren JD, Hicks JM, Garner HR. eTBLAST: a web server to identify expert reviewers, appropriate journals and similar publications. Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W12-5. PMID: 17452348.
      Citations: 19     Fields:    Translation:Humans
    156. Perez-Iratxeta C, Andrade-Navarro MA, Wren JD. Evolving research trends in bioinformatics. Brief Bioinform. 2007 Mar; 8(2):88-95. PMID: 17077138.
      Citations: 13     Fields:    
    157. Wren JD, Gusev Y, Ptitsyn A, Winters-Hilt S. Proceedings of the Third Annual Conference of the MidSouth Computational Biology and Bioinformatics Society. Introduction. BMC Bioinformatics. 2006 Sep 06; 7 Suppl 2:S1. PMID: 17118130.
      Citations:    Fields:    
    158. Wren JD. A scalable machine-learning approach to recognize chemical names within large text databases. BMC Bioinformatics. 2006 Sep 06; 7 Suppl 2:S3. PMID: 17118146.
      Citations: 11     Fields:    
    159. Wren JD, Johnson KR, Crockett DM, Heilig LF, Schilling LM, Dellavalle RP. Uniform resource locator decay in dermatology journals: author attitudes and preservation practices. Arch Dermatol. 2006 Sep; 142(9):1147-52. PMID: 16983002.
      Citations: 6     Fields:    Translation:Humans
    160. Wren JD. Theory and reality for software patents: good in concept, not so good in practice. Bioinformatics. 2006 Jul 01; 22(13):1543-5. PMID: 16801635.
      Citations:    Fields:    
    161. Flood EM, Kumar RS, Shah R, Amos Q, Wren JD, Shohet RV, Garner HR. Melatonin administration does not affect isoproterenol-induced LVH. IEEE Eng Med Biol Mag. 2006 May-Jun; 25(3):84-7. PMID: 16764435.
      Citations: 1     Fields:    Translation:HumansAnimals
    162. Wren JD, Roossinck MJ, Nelson RS, Scheets K, Palmer MW, Melcher U. Plant virus biodiversity and ecology. PLoS Biol. 2006 Mar; 4(3):e80. PMID: 16524342.
      Citations: 24     Fields:    Translation:AnimalsCells
    163. Wren JD, Grissom JE, Conway T. E-mail decay rates among corresponding authors in MEDLINE. The ability to communicate with and request materials from authors is being eroded by the expiration of e-mail addresses. . 2006 Feb; 7(2):122-7. PMID: 16452921.
      Citations:    
    164. Wren JD, Conway T. Meta-analysis of published transcriptional and translational fold changes reveals a preference for low-fold inductions. OMICS. 2006; 10(1):15-27. PMID: 16584315.
      Citations: 12     Fields:    Translation:Cells
    165. Wren JD. Truth, probability, and frameworks. PLoS Med. 2005 Nov; 2(11):e361. PMID: 16288554.
      Citations:    Fields:    Translation:Humans
    166. Wren JD, Hildebrand WH, Chandrasekaran S, Melcher U. Markov model recognition and classification of DNA/protein sequences within large text databases. Bioinformatics. 2005 Nov 01; 21(21):4046-53. PMID: 16159926.
      Citations: 6     Fields:    
    167. Wren JD, Johnson D, Gruenwald L. Automating genomic data mining via a sequence-based matrix format and associative rule set. BMC Bioinformatics. 2005 Jul 15; 6 Suppl 2:S2. PMID: 16026599.
      Citations: 5     Fields:    Translation:Cells
    168. Xu Z, Patterson TA, Wren JD, Han T, Shi L, Duhart H, Ali SF, Slikker W. A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools. BMC Bioinformatics. 2005 Jul 15; 6 Suppl 2:S8. PMID: 16026605.
      Citations: 6     Fields:    Translation:AnimalsCells
    169. Wren JD, Garner HR. Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. J Biomed Biotechnol. 2005 Jun 30; 2005(2):104-12. PMID: 16046815.
      Citations: 21     Fields:    
    170. Wren JD. Open access and openly accessible: a study of scientific publications shared via the internet. BMJ. 2005 May 14; 330(7500):1128. PMID: 15827063.
      Citations: 10     Fields:    
    171. Mizumoto N, Hui F, Edelbaum D, Weil MR, Wren JD, Shalhevet D, Matsue H, Liu L, Garner HR, Takashima A. Differential activation profiles of multiple transcription factors during dendritic cell maturation. J Invest Dermatol. 2005 Apr; 124(4):718-24. PMID: 15816829.
      Citations: 6     Fields:    Translation:AnimalsCells
    172. Wren JD, Chang JT, Pustejovsky J, Adar E, Garner HR, Altman RB. Biomedical term mapping databases. Nucleic Acids Res. 2005 Jan 01; 33(Database issue):D289-93. PMID: 15608198.
      Citations: 14     Fields:    
    173. Jennings SF, Ptitsyn AA, Wilkins D, Bruhn RE, Slikker W, Wren JD. Regional societies: fostering competitive research through virtual infrastructures. PLoS Biol. 2004 Dec; 2(12):e372. PMID: 15597114.
      Citations: 3     Fields:    
    174. Wren JD. Extending the mutual information measure to rank inferred literature relationships. BMC Bioinformatics. 2004 Oct 07; 5:145. PMID: 15471547.
      Citations: 28     Fields:    Translation:Humans
    175. Wren JD, Yao M, Langer M, Conway T. Simulated annealing of microarray data reduces noise and enables cross-experimental comparisons. DNA Cell Biol. 2004 Oct; 23(10):695-700. PMID: 15585127.
      Citations: 2     Fields:    Translation:Cells
    176. Schilling LM, Wren JD, Dellavalle RP. Bioinformatics leads charge by publishing more Internet addresses in abstracts than any other journal. Bioinformatics. 2004 Nov 22; 20(17):2903. PMID: 15231533.
      Citations: 1     Fields:    
    177. Wren JD. The emerging in-silico scientist: how text-based bioinformatics is bridging biology and artificial intelligence. IEEE Eng Med Biol Mag. 2004 Mar-Apr; 23(2):87-93. PMID: 15264477.
      Citations: 2     Fields:    
    178. Wren JD. 404 not found: the stability and persistence of URLs published in MEDLINE. Bioinformatics. 2004 Mar 22; 20(5):668-72. PMID: 15033874.
      Citations: 19     Fields:    
    179. Wren JD, Bekeredjian R, Stewart JA, Shohet RV, Garner HR. Knowledge discovery by automated identification and ranking of implicit relationships. Bioinformatics. 2004 Feb 12; 20(3):389-98. PMID: 14960466.
      Citations: 75     Fields:    
    180. Wren JD, Garner HR. Shared relationship analysis: ranking set cohesion and commonalities within a literature-derived relationship network. Bioinformatics. 2004 Jan 22; 20(2):191-8. PMID: 14734310.
      Citations: 40     Fields:    
    181. Kulkarni AV, Williams NS, Lian Y, Wren JD, Mittelman D, Pertsemlidis A, Garner HR. ARROGANT: an application to manipulate large gene collections. Bioinformatics. 2002 Nov; 18(11):1410-7. PMID: 12424110.
      Citations: 3     Fields:    Translation:HumansCells
    182. Wren JD, Mittelman DA, Garner HR. SIGNAL-Sequence Information and GeNomic AnaLysis. Comput Methods Programs Biomed. 2002 May; 68(2):177-81. PMID: 11932033.
      Citations: 1     Fields:    
    183. Wren JD, Kulkarni A, Joslin J, Butow RA, Garner HR. Cross-hybridization on PCR-spotted microarrays. IEEE Eng Med Biol Mag. 2002 Mar-Apr; 21(2):71-5. PMID: 12012609.
      Citations: 12     Fields:    Translation:AnimalsCells
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