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Hiroshi Yamada

TitleProf,Asst of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Hematology/Oncology
AddressBRC 1203
975 NE 10th St
Oklahoma City OK 73104
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    R03CA162538     (YAMADA, HIROSHI Y)Apr 1, 2012 - Nov 1, 2014
    Understanding the role of Sgo1 in colorectal cancer
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rao CV, Yamada HY. How would preclinical Alzheimer's disease (AD pathology) occur? An insight from a genomic instability mouse model. Neural Regen Res. 2021 Oct; 16(10):2012-2014. PMID: 33642383.
    2. La TM, Tachibana H, Li SA, Abe T, Seiriki S, Nagaoka H, Takashima E, Takeda T, Ogawa D, Makino SI, Asanuma K, Watanabe M, Tian X, Ishibe S, Sakane A, Sasaki T, Wada J, Takei K, Yamada H. Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes. FASEB J. 2020 12; 34(12):16449-16463. PMID: 33070431.
    3. Rao CV, Farooqui M, Madhavaram A, Zhang Y, Asch AS, Yamada HY. GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-ß accumulation and neuroinflammation in middle-aged Shugoshin 1 mice. Aging Cell. 2020 10; 19(10):e13221. PMID: 32857910.
      Citations: 1     Fields:    
    4. Iketani R, Furushima D, Imai S, Yamada H. Efficacy and safety of atypical antipsychotics for psychosis in Parkinson's disease: A systematic review and Bayesian network meta-analysis. Parkinsonism Relat Disord. 2020 09; 78:82-90. PMID: 32755800.
      Citations:    Fields:    
    5. Rao CV, Asch AS, Carr DJJ, Yamada HY. "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13109. PMID: 31981470.
      Citations: 6     Fields:    
    6. Abe T, La TM, Miyagaki Y, Oya E, Wei FY, Sumida K, Fujise K, Takeda T, Tomizawa K, Takei K, Yamada H. [Corrigendum]Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells. Int J Oncol. 2020 03; 56(3):859. PMID: 32124951.
      Citations:    Fields:    
    7. Lee Y, Yamada H, Pradipta A, Ma JS, Okamoto M, Nagaoka H, Takashima E, Standley DM, Sasai M, Takei K, Yamamoto M. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Life Sci Alliance. 2020 01; 3(1). PMID: 31852733.
      Citations: 4     Fields:    Translation:AnimalsCells
    8. Nishida N, Aoki H, Ohno-Urabe S, Nishihara M, Furusho A, Hirakata S, Hayashi M, Ito S, Yamada H, Hirata Y, Yasukawa H, Imaizumi T, Tanaka H, Fukumoto Y. High Salt Intake Worsens Aortic Dissection in Mice: Involvement of IL (Interleukin)-17A-Dependent ECM (Extracellular Matrix) Metabolism. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):189-205. PMID: 31694392.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Féraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blasér S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M. ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 04 15; 129(5):2145-2162. PMID: 30985297.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    10. Abe T, La TM, Miyagaki Y, Oya E, Wei FY, Sumida K, Fujise K, Takeda T, Tomizawa K, Takei K, Yamada H. Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells. Int J Oncol. 2019 Feb; 54(2):550-558. PMID: 30570111.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Rao CV, Farooqui M, Asch AS, Yamada HY. Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model. . 2018; 17(19-20):2321-2334. PMID: 30231670.
    12. Rao CV, Farooqui M, Zhang Y, Asch AS, Yamada HY. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018 08; 17(4):e12797. PMID: 29943428.
      Citations: 8     Fields:    Translation:Animals
    13. Iketani R, Ohno K, Kawasaki Y, Matsumoto K, Yamada H, Kishino S. Apolipoprotein E Gene Polymorphisms Affect the Efficacy of Thiazolidinediones for Alzheimer's Disease: A Systematic Review and Meta-Analysis. Biol Pharm Bull. 2018; 41(7):1017-1023. PMID: 29962398.
      Citations: 1     Fields:    Translation:Humans
    14. Rao CV, Pal S, Mohammed A, Farooqui M, Doescher MP, Asch AS, Yamada HY. Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo. Oncotarget. 2017 Aug 22; 8(34):57605-57621. PMID: 28915699.
      Citations: 12     Fields:    
    15. Hayashi M, Aoshi T, Haseda Y, Kobiyama K, Wijaya E, Nakatsu N, Igarashi Y, Standley DM, Yamada H, Honda-Okubo Y, Hara H, Saito T, Takai T, Coban C, Petrovsky N, Ishii KJ. Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines. EBioMedicine. 2017 Feb; 15:127-136. PMID: 27919753.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    16. Rao CV, Asch AS, Yamada HY. Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer. Carcinogenesis. 2017 01; 38(1):2-11. PMID: 27838634.
      Citations: 28     Fields:    Translation:HumansCells
    17. Rao CV, Asch AS, Yamada HY. Emerging links among Chromosome Instability (CIN), cancer, and aging. Mol Carcinog. 2017 03; 56(3):791-803. PMID: 27533343.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    18. Yamada HY, Kumar G, Zhang Y, Rubin E, Lightfoot S, Dai W, Rao CV. Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung. Oncogenesis. 2016 Aug 15; 5(8):e256. PMID: 27526110.
    19. Yamada H, Takeda T, Michiue H, Abe T, Takei K. Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells. Int J Oncol. 2016 Sep; 49(3):877-86. PMID: 27572123.
      Citations: 15     Fields:    Translation:HumansCells
    20. Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016 Mar 18; 6:23372. PMID: 26988603.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    21. Rao CV, Sanghera S, Zhang Y, Biddick L, Reddy A, Lightfoot S, Janakiram NB, Mohammed A, Dai W, Yamada HY. Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice. Cancer Res. 2016 Feb 01; 76(3):630-42. PMID: 26833665.
      Citations: 11     Fields:    Translation:Animals
    22. Mohammed A, Janakiram NB, Madka V, Brewer M, Ritchie RL, Lightfoot S, Kumar G, Sadeghi M, Patlolla JM, Yamada HY, Cruz-Monserrate Z, May R, Houchen CW, Steele VE, Rao CV. Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. Oncotarget. 2015 Jun 20; 6(17):15524-39. PMID: 25906749.
      Citations: 21     Fields:    Translation:AnimalsCells
    23. Rao CV, Sanghera S, Zhang Y, Biddick L, Reddy A, Lightfoot S, Dai W, Yamada HY. Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. Mol Carcinog. 2016 May; 55(5):600-10. PMID: 25773652.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Yamada HY, Zhang Y, Reddy A, Mohammed A, Lightfoot S, Dai W, Rao CV. Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis. 2015 Apr; 36(4):429-40. PMID: 25740822.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Terami N, Ogawa D, Tachibana H, Hatanaka T, Wada J, Nakatsuka A, Eguchi J, Horiguchi CS, Nishii N, Yamada H, Takei K, Makino H. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS One. 2014; 9(6):e100777. PMID: 24960177.
      Citations: 68     Fields:    Translation:AnimalsCells
    26. Omura K, Uehara T, Morikawa Y, Hayashi H, Mitsumori K, Minami K, Kanki M, Yamada H, Ono A, Urushidani T. Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats. J Toxicol Sci. 2014; 39(5):785-94. PMID: 25242409.
      Citations: 1     Fields:    Translation:Animals
    27. Omura K, Uehara T, Morikawa Y, Hayashi H, Mitsumori K, Minami K, Kanki M, Yamada H, Ono A, Urushidani T. Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model. J Toxicol Sci. 2014; 39(6):837-48. PMID: 25374375.
      Citations: 1     Fields:    Translation:AnimalsCells
    28. Rao CV, Yamada HY. Genomic instability and colon carcinogenesis: from the perspective of genes. Front Oncol. 2013; 3:130. PMID: 23734346.
    29. Yamada H, Abe T, Satoh A, Okazaki N, Tago S, Kobayashi K, Yoshida Y, Oda Y, Watanabe M, Tomizawa K, Matsui H, Takei K. Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia. J Neurosci. 2013 Mar 06; 33(10):4514-26. PMID: 23467367.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    30. Rao CV, Kurkjian CD, Yamada HY. Mitosis-targeting natural products for cancer prevention and therapy. Curr Drug Targets. 2012 Dec; 13(14):1820-30. PMID: 23140292.
      Citations: 14     Fields:    Translation:HumansAnimals
    31. Hirata T, Watanabe M, Kaku H, Kobayashi Y, Yamada H, Sakaguchi M, Takei K, Huh NH, Nasu Y, Kumon H. REIC/Dkk-3-encoding adenoviral vector as a potentially effective therapeutic agent for bladder cancer. Int J Oncol. 2012 Aug; 41(2):559-64. PMID: 22665039.
      Citations: 8     Fields:    Translation:HumansCells
    32. Ueki H, Watanabe M, Kaku H, Huang P, Li SA, Ochiai K, Hirata T, Noguchi H, Yamada H, Takei K, Nasu Y, Kashiwakura Y, Kumon H. A novel gene expression system for detecting viable bladder cancer cells. Int J Oncol. 2012 Jul; 41(1):135-40. PMID: 22470055.
      Citations: 4     Fields:    Translation:HumansCells
    33. Yamada HY, Yao Y, Wang X, Zhang Y, Huang Y, Dai W, Rao CV. Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. . 2012 Feb 01; 11(3):479-88. PMID: 22262168.
    34. Uehara T, Minowa Y, Morikawa Y, Kondo C, Maruyama T, Kato I, Nakatsu N, Igarashi Y, Ono A, Hayashi H, Mitsumori K, Yamada H, Ohno Y, Urushidani T. Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database. Toxicol Appl Pharmacol. 2011 Sep 15; 255(3):297-306. PMID: 21784091.
      Citations: 22     Fields:    Translation:Animals
    35. Kahyo T, Iwaizumi M, Shinmura K, Matsuura S, Nakamura T, Watanabe Y, Yamada H, Sugimura H. A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion. Oncogene. 2011 Nov 03; 30(44):4453-63. PMID: 21532624.
      Citations: 17     Fields:    Translation:HumansCells
    36. Zhang K, Watanabe M, Kashiwakura Y, Li SA, Edamura K, Huang P, Yamaguchi K, Nasu Y, Kobayashi Y, Sakaguchi M, Ochiai K, Yamada H, Takei K, Ueki H, Huh NH, Li M, Kaku H, Na Y, Kumon H. Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development. Int J Oncol. 2010 Dec; 37(6):1495-501. PMID: 21042718.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    37. Yamada HY, Rao CV. Genes that modulate the sensitivity for anti-microtubule drug-mediated chemotherapy. Curr Cancer Drug Targets. 2010 Sep; 10(6):623-33. PMID: 20491618.
      Citations: 3     Fields:    Translation:HumansCells
    38. Yamada HY, Rao CV. BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy. Int J Oncol. 2009 Nov; 35(5):1101-9. PMID: 19787264.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    39. Rao CV, Yamada HY, Yao Y, Dai W. Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis. 2009 Sep; 30(9):1469-74. PMID: 19372138.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    40. Shinmura K, Iwaizumi M, Igarashi H, Nagura K, Yamada H, Suzuki M, Fukasawa K, Sugimura H. Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). J Pathol. 2008 Nov; 216(3):365-74. PMID: 18788085.
      Citations: 14     Fields:    Translation:HumansCells
    41. Iwaizumi M, Shinmura K, Mori H, Yamada H, Suzuki M, Kitayama Y, Igarashi H, Nakamura T, Suzuki H, Watanabe Y, Hishida A, Ikuma M, Sugimura H. Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut. 2009 Feb; 58(2):249-60. PMID: 18635744.
      Citations: 39     Fields:    Translation:HumansCells
    42. Sato Y, Yamada H, Iwasaki K, Tateno C, Yokoi T, Yoshizato K, Horii I. Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen. Toxicol Pathol. 2008 Jun; 36(4):581-91. PMID: 18467679.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    43. Yamamoto T, Tomizawa K, Fujikawa M, Sato Y, Yamada H, Horii I. Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches--effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine. J Toxicol Sci. 2007 Aug; 32(3):205-15. PMID: 17785938.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Yamada HY, Gorbsky GJ. Spindle checkpoint function and cellular sensitivity to antimitotic drugs. . 2006 Dec; 5(12):2963-9. PMID: 17172401.
    45. Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S, Nakano S, Katoh M, Ito H, Oshimura M. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene. 2007 Feb 15; 26(7):945-57. PMID: 16909107.
      Citations: 80     Fields:    Translation:HumansCells
    46. Yamada HY, Gorbsky GJ. Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest. Biol Proced Online. 2006; 8:36-43. PMID: 16799695.
    47. Yamada HY, Gorbsky GJ. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Oncogene. 2006 Mar 02; 25(9):1330-9. PMID: 16314844.
      Citations: 10     Fields:    Translation:HumansCells
    48. Yamada HY, Gorbsky GJ. Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. Mol Cancer Ther. 2006 Jan; 5(1):29-38. PMID: 16432160.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    49. Kashiwakura Y, Watanabe M, Kusumi N, Sumiyoshi K, Nasu Y, Yamada H, Sawamura T, Kumon H, Takei K, Daida H. Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Circulation. 2004 Nov 23; 110(21):3329-34. PMID: 15545517.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    50. Klinman DM, Zeuner R, Yamada H, Gursel M, Currie D, Gursel I. Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides. Ann N Y Acad Sci. 2003 Dec; 1002:112-23. PMID: 14751829.
      Citations: 8     Fields:    Translation:AnimalsCells
    51. Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, Klinman DM. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol. 2003 Aug 01; 171(3):1393-400. PMID: 12874230.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    52. Yamada H, Gursel I, Takeshita F, Conover J, Ishii KJ, Gursel M, Takeshita S, Klinman DM. Effect of suppressive DNA on CpG-induced immune activation. J Immunol. 2002 Nov 15; 169(10):5590-4. PMID: 12421936.
      Citations: 24     Fields:    Translation:AnimalsCells
    53. Yamada H, Ichikawa W, Uetake H, Shirota Y, Nihei Z, Sugihara K, Hirayama R. Thymidylate synthase gene expression in primary colorectal cancer and metastatic sites. Clin Colorectal Cancer. 2001 Nov; 1(3):169-73; discussion 174. PMID: 12450430.
      Citations: 8     Fields:    Translation:Humans
    54. Wang X, Ohnishi M, Wada A, Tsutamoto T, Sawaki M, Fujii M, Matsumoto T, Yamamoto T, Kurokawa K, Yamada H, Kinoshita M. Endothelin-1 promotes vascular structural remodeling during the progression of heart failure prevention of vascular remodeling using a specific endothelin-converting enzyme inhibitor. Life Sci. 2001 Oct 12; 69(21):2477-88. PMID: 11693256.
      Citations: 1     Fields:    Translation:Animals
    55. Matsuda T, Sasaki M, Kato H, Yamada H, Cohen M, Barrett JC, Oshimura M, Wake N. Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma. Oncogene. 1997 Dec 04; 15(23):2773-81. PMID: 9419968.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    56. Zhang Y, Kiyohara H, Matsumoto T, Yamada H. Fractionation and chemical properties of immunomodulating polysaccharides from roots of Dipsacus asperoides. Planta Med. 1997 Oct; 63(5):393-9. PMID: 9342940.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    57. Koi M, Morita H, Yamada H, Satoh H, Barrett JC, Oshimura M. Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa. Mol Carcinog. 1989; 2(1):12-21. PMID: 2730761.
      Citations: 31     Fields:    Translation:HumansCells
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